Which of the following is true about oxygen binding to hemoglobin:
a. oxygen binding at the four binding sites shows positive cooperativity
b. fractional saturation of hemoglobin results in a sigmoidal curve
c. the allosteric effector bisphosphoglycerate (BPG) reduces the affinity for oxygen
d. oxygen is coordinated at the iron center of a heme group
e. all the above statements are true
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