Clutch Prep is now a part of Pearson
Ch. 7 - Enzyme Inhibition and Regulation WorksheetSee all chapters
All Chapters
Ch. 1 - Introduction to Biochemistry
Ch. 2 - Water
Ch. 3 - Amino Acids
Ch. 4 - Protein Structure
Ch. 5 - Protein Techniques
Ch. 6 - Enzymes and Enzyme Kinetics
Ch. 7 - Enzyme Inhibition and Regulation
Ch. 8 - Protein Function
Ch. 9 - Carbohydrates
Ch. 10 - Lipids
Ch. 11 - Biological Membranes and Transport
Ch. 12 - Biosignaling
Clutch Review 1: Nucleic Acids, Lipids, & Membranes
Clutch Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Clutch Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism
Clutch Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation
Enzyme Inhibition
Irreversible Inhibition
Reversible Inhibition
Inhibition Constant
Degree of Inhibition
Apparent Km and Vmax
Inhibition Effects on Reaction Rate
Competitive Inhibition
Uncompetitive Inhibition
Mixed Inhibition
Noncompetitive Inhibition
Recap of Reversible Inhibition
Allosteric Regulation
Allosteric Kinetics
Allosteric Enzyme Conformations
Allosteric Effectors
Concerted (MWC) Model
Sequential (KNF) Model
Negative Feedback
Positive Feedback
Post Translational Modification

Concept #1: Uncompetitive Inhibition

Concept #2: Uncompetitive Inhibitor Effects

Concept #3: Uncompetitive Inhibition & Michaelis-Menten-Plots

Concept #4: Uncompetitive Inhibition & Lineweaver-Burk-Plots

Practice: True or false: Increasing [S] in the presence of an uncompetitive inhibitor will lower the inhibition constant (KI).

Practice: In the presence of an uncompetitive inhibitor that binds __________ the substrate, the apparent Vmax ____________ and the apparent Km ____________ with respect to the Vmax and Km of the uninhibited enzyme.

Practice: What is the effect of an uncompetitive inhibitor on the equilibrium between free enzyme & the ES-complex?

Practice: Which of the following statements is true about uncompetitive inhibitors?