Introduction to Protein-Ligand Interactions
Protein-Ligand Equilibrium Constants
Protein-Ligand Fractional Saturation
Myoglobin vs. Hemoglobin
Heme Prosthetic Group
Hemoglobin Cooperativity
Hill Equation
Hill Plot
Hemoglobin Binding in Tissues & Lungs
Hemoglobin Carbonation & Protonation
Bohr Effect
BPG Regulation of Hemoglobin
Fetal Hemoglobin
Sickle Cell Anemia
Chymotrypsin's Catalytic Mechanism
Glycogen Phosphorylase
Liver vs Muscle Glycogen Phosphorylase
Motor Proteins
Skeletal Muscle Anatomy
Skeletal Muscle Contraction

Concept #1: Sliding Filament Model

Practice: Which statement best describes the sliding filament model of a sarcomere contraction?

Concept #2: Actomyosin Cycle Leads to Muscle Contraction

Concept #3: Actomyosin Cycle

Practice: Fill-in the blanks with numbers (1-7) to put the events of the actomyosin cycle in order from beginning to end:

a) _____: Myosin releases Pi.

b) 1 : Myosin binds ATP.

c) _____: Myosin head bonds tightly to thin actin filament.

d) _____: Myosin power stroke occurs.

e) _____: Myosin-actin interaction is broken.

f) _____: Myosin head pivots to a high-energy state.

g) _____: Myosin hydrolyzes ATP to ADP and Pi.

Concept #4: Muscle Relaxation via Troponin & Tropomyosin Regulation

Practice: Muscle contraction is directly caused by:

Practice: Which of the following does not occur during a muscle contraction?

Practice: Which of the following is false concerning the sliding-filament model of muscle contraction?

Practice: Which of the following statements correctly describes the relationship between cytosolic [Ca2+] and the corresponding sarcomere response?