Concept #1: Noncompetitive Inhibition

Concept #2: Noncompetitive Inhibitor Effects

Concept #3: Noncompetitive Inhibition & Michaelis-Menten-Plots

Concept #4: Noncompetitive Inhibition & Lineweaver-Burk-Plots

Practice: Indicate with an “x” which of the kinetic parameters would be altered in the presence of the given inhibitor.

Practice: What can be determined from the following Lineweaver Burk plot?

Practice: How would you expect the line on a Lineweaver-Burk plot to change if the enzyme was treated with a noncompetitive inhibitor?

Practice: The following values were determined for alcohol dehydrogenase in the absence & presence of acetaldehyde. What kind of inhibitor is acetaldehyde?