Concept #1: Negative Feedback

Example #1: Feedback Regulation in Glycolysis

Practice: The scheme below represents a hypothetical metabolic pathway for the synthesis of compound Y. The pathway is regulated by feedback inhibition. If S → T is the rate-limiting step, circle what the most likely inhibitor is and indicate with an arrow where the inhibition most likely occurs:

S → T → U → V → W → X → Y

Practice: A metabolic pathway proceeds according to the following scheme: R → S → T → U → V → W. A regulatory enzyme, X, catalyzes the first reaction in the pathway. Which of the following is most likely correct for this pathway?

Practice: Which of the following is TRUE about feedback inhibition?