Introduction to Protein-Ligand Interactions
Protein-Ligand Equilibrium Constants
Protein-Ligand Fractional Saturation
Myoglobin vs. Hemoglobin
Heme Prosthetic Group
Hemoglobin Cooperativity
Hill Equation
Hill Plot
Hemoglobin Binding in Tissues & Lungs
Hemoglobin Carbonation & Protonation
Bohr Effect
BPG Regulation of Hemoglobin
Fetal Hemoglobin
Sickle Cell Anemia
Chymotrypsin's Catalytic Mechanism
Glycogen Phosphorylase
Liver vs Muscle Glycogen Phosphorylase
Motor Proteins
Skeletal Muscle Anatomy
Skeletal Muscle Contraction

Concept #1: Allosteric Regulation of Glycogen Phosphorylase a

Practice: A patient comes into your clinic suffering from anorexia nervosa. Her mother brought her in concerned as the patient has not eaten in over 3 days. She has the classic presentation including low body weight, decreased muscle mass, decreased glycogen, and decreased fat stores, and she is anemic (low red blood cell count). What would be the expected phosphorylation state and activity of the patient’s liver glycogen phosphorylase?

Concept #2: Allosteric Regulation of Glycogen Phosphorylase b

Practice: Muscle glycogen phosphorylase displays multiple modes of allosteric regulation. Which of the following is true?