Practice: The addition of the nonhydrolyzable GTP-analog, GTPγS (shown below), is a common cell culture technique. If only affecting the inhibitory pathway, what effect would GTPγS have on cellular cAMP levels?
Concept #1: Inhibitory Adenylate Cyclase GPCR Signaling
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Practice: The addition of the nonhydrolyzable GTP-analog, GTPγS (shown below), is a common cell culture technique. If only affecting the inhibitory pathway, what effect would GTPγS have on cellular cAMP levels?
Practice: If a chemical is an inhibitor of the enzyme adenylyl cyclase, which of the following steps in the GPCR signaling pathway would be directly blocked?
Concept #2: GPCR Desensitization
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Example #1: What conclusion can be made from the results/data?
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Practice: How does GPCR termination differ from GPCR desensitization?
Practice: Which of the following statements about beta-arrestin and GPCRs is TRUE?
Practice: Which of the following are involved in the desensitization of the β-adrenergic receptor?
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