Introduction to Protein-Ligand Interactions
Protein-Ligand Equilibrium Constants
Protein-Ligand Fractional Saturation
Myoglobin vs. Hemoglobin
Heme Prosthetic Group
Hemoglobin Cooperativity
Hill Equation
Hill Plot
Hemoglobin Binding in Tissues & Lungs
Hemoglobin Carbonation & Protonation
Bohr Effect
BPG Regulation of Hemoglobin
Fetal Hemoglobin
Sickle Cell Anemia
Chymotrypsin's Catalytic Mechanism
Glycogen Phosphorylase
Liver vs Muscle Glycogen Phosphorylase
Motor Proteins
Skeletal Muscle Anatomy
Skeletal Muscle Contraction

Concept #2: Mb’s Hill Plot

Concept #3: Hb's Hill Plot

Concept #4: Hb's Lowest O2-Affinity State 

Concept #5: Hb's Cooperative State

Concept #6: Hb's Highest O2-Affinity State

Concept #7: Hill Plot Breakdown

Concept #8: "Velocity" & "Acceleration"

Practice: Which of the following situations would produce a Hill plot with n H < 1.0?

Practice: Label the axis of the Hill Plot below & fill-in the graph with Mb’s & Hb’s approximate O2-binding data.

Practice: The slope of a Hill plot for hemoglobin _______________; whereas that for myoglobin ________________.