Concept #1: Cooperative Ligand-Binging in Allosteric Proteins

Concept #2: The Hill Equation

Concept #3: The Hill Equation 

Practice: At a CO2 partial pressure of 5 torr, the  p50 value for hemoglobin is 26 torr. What is the fractional saturation when nH = 3 and pO2 = 25 torr, a typical venous oxygen partial pressure?

Practice: What is Hb’s fractional saturation when p50 = 26 torr, nH = 3, and pO2 = 100 torr, a typical pO2 in the lungs?