Concept #1: Hemoglobin Carbonation (HbCO2) in the Tissues

Practice: Which option best corresponds with the effect of CO2 on hemoglobin’s O2-binding?

Concept #2: Hemoglobin Protonation (HHb+) in the Tissues 

Practice: Which statement is true about protons binding to hemoglobin?

Concept #3: Hemoglobin Carbonation & Protonation Recap 

Practice: Alkalemia is a disease associated with an abnormal increase in the pH of a patient’s blood due to rapid breathing (hyperventilation). How would alkalemia affect the oxygen binding affinity of the patient’s hemoglobin?

Practice: Choose all of the following molecules that, when bound, trigger hemoglobin’s transition from T to R state.