Sections
Introduction to Protein-Ligand Interactions
Protein-Ligand Equilibrium Constants
Protein-Ligand Fractional Saturation
Myoglobin vs. Hemoglobin
Heme Prosthetic Group
Hemoglobin Cooperativity
Hill Equation
Hill Plot
Hemoglobin Binding in Tissues & Lungs
Hemoglobin Carbonation & Protonation
Bohr Effect
BPG Regulation of Hemoglobin
Fetal Hemoglobin
Sickle Cell Anemia
Chymotrypsin
Chymotrypsin's Catalytic Mechanism
Glycogen Phosphorylase
Liver vs Muscle Glycogen Phosphorylase
Antibody
ELISA
Motor Proteins
Skeletal Muscle Anatomy
Skeletal Muscle Contraction

Concept #1: Hemoglobin Carbonation (HbCO2) in the Tissues

Practice: Which option best corresponds with the effect of CO2 on hemoglobin’s O2-binding?

Concept #2: Hemoglobin Protonation (HHb+) in the Tissues 

Practice: Which statement is true about protons binding to hemoglobin?

Concept #3: Hemoglobin Carbonation & Protonation Recap 

Practice: Alkalemia is a disease associated with an abnormal increase in the pH of a patient’s blood due to rapid breathing (hyperventilation). How would alkalemia affect the oxygen binding affinity of the patient’s hemoglobin?

Practice: Choose all of the following molecules that, when bound, trigger hemoglobin’s transition from T to R state.