Concept #1: Why is the Heme Group on Hb/Mb Important?

Concept #2: Structure of Heme

Concept #3: Structure of Heme 

Concept #4: Interactions of Fe2+ In the Heme

Practice: When O2 binds to a heme group, the two bonds of Fe2+ that are not planar with the heme are occupied by:

Concept #5: Myoglobin's Heme Interactions

Practice: The distal histidine residue in myoglobin acts to:

Concept #6: Heme O2's Binding Causes Conformational Changes

Practice: In hemoglobin, the equilibrium transition from T state to R state is triggered by: