Practice: In hemoglobin, the equilibrium transition from R state to T state is triggered by:
Concept #1: BPG Effect on Oxygen Binding
Concept #2: BPG Only Affects Hb in the Tissues
Concept #3: Physiological Regulation of [BPG]
Practice: A 9-month old girl with hemolytic anemia is found to have a deficiency in the enzyme responsible for the conversion of molecule-B to pyruvate. Shown below is the oxygen saturation curve for hemoglobin in the erythrocytes of this patient (green curve), compared to the corresponding black curve in normal red blood cells. Which of the following is the most likely explanation for the observed oxygen saturation curve in this patient?
Practice: What is the effect of the following changes on the O 2 affinity of hemoglobin?
A) A drop in the pH of blood plasma from 7.4 to 7.2.
a) Lower the O2 Affinity. b) Increase the O2 Affinity.
B) A decrease in the partial pressure of CO2 in the lungs from 6 kPa (holding one's breath) to 2 kPa (normal).
a) Lower the O2 Affinity. b) Increase the O2 Affinity.
C) An increase in [BPG] from 5 mM (normal altitudes) to 8 mM (high altitudes).
a) Lower the O2 Affinity. b) Increase the O2 Affinity.
