Concept #1: Allosteric Enzyme Conformations

Concept #2: T State & R State

Concept #3: Allosteric Constant (L0)

Practice: Which of the following is true about allosteric enzyme conformational states?

Concept #4: T/R Conformations Allow for Cooperative Kinetics

Concept #5: L0 Dictates Curve in Kinetics Plots

Practice: An allosteric enzyme that follows the concerted model mechanism has a L 0 = 10,000 in the absence of substrate. A mutation in this enzyme caused the L0 to now be 1/10,000 (reciprocal to its original value). What affect does this mutation have on the reaction rate of the enzymatic reaction?