Ch. 7 - Enzyme Inhibition and Regulation WorksheetSee all chapters
All Chapters
Ch. 1 - Introduction to Biochemistry
Ch. 2 - Water
Ch. 3 - Amino Acids
Ch. 4 - Protein Structure
Ch. 5 - Protein Techniques
Ch. 6 - Enzymes and Enzyme Kinetics
Ch. 7 - Enzyme Inhibition and Regulation
Ch. 8 - Protein Function
Ch. 9 - Carbohydrates
Ch. 10 - Lipids
Ch. 11 - Biological Membranes and Transport
Ch. 12 - Biosignaling
Clutch Review 1: Nucleic Acids, Lipids, & Membranes
Clutch Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Clutch Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism
Clutch Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation
Sections
Enzyme Inhibition
Irreversible Inhibition
Reversible Inhibition
Inhibition Constant
Degree of Inhibition
Apparent Km and Vmax
Inhibition Effects on Reaction Rate
Competitive Inhibition
Uncompetitive Inhibition
Mixed Inhibition
Noncompetitive Inhibition
Recap of Reversible Inhibition
Allosteric Regulation
Allosteric Kinetics
Allosteric Enzyme Conformations
Allosteric Effectors
Concerted (MWC) Model
Sequential (KNF) Model
Negative Feedback
Positive Feedback
Post Translational Modification
Ubiquitination
Phosphorylation
Zymogens

Concept #1: Allosteric Effectors

Concept #2: Activators vs. Inhibitors

Practice: L-arginine is capable of binding to and activating N-acetylglutamate synthase. Since L-arginine is neither a substrate nor a product of this enzyme, how would this effector be classified?

Practice: Considering that O2 triggers hemoglobin to switch from its low affinity (T) state to its high affinity (R) state to bind more O2, what kind of allosteric effector is O 2 relative to hemoglobin?

Practice: Which of the following statements about allosteric control of enzymatic activity is false?

Practice: The effectiveness of allosteric effectors in regulating metabolic pathways is based on their ability to:

Practice: Shown below is a branched reaction pathway in which either “D” or “E” can be made from “C”, depending on which enzymes are active. Imagine that you are a cell that requires “E” to be at a minimum threshold concentration for survival, but as long as there is enough “E”, it is most beneficial for the cell to make “D.” Which of the following options presents the best scenario for the most optimal survival conditions? E1-E4 are enzymes that catalyze each of the reactions.